Photosensitized formation of 8-hydroxy-2'-deoxyguanosine and DNA strand breakage by a cationic meso-substituted porphyrin.

Abstract

Cationic porphyrins, known to have a high affinity for DNA, are useful tools with which to probe a variety of interactions with DNA. In this study we have examined both DNA strand scission and oxidative DNA base damage, measured by 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation, using a photoactivated cis-dicationic porphyrin. The data demonstrated a dose… (More)

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Cite this paper

@article{Nicotera1994PhotosensitizedFO, title={Photosensitized formation of 8-hydroxy-2'-deoxyguanosine and DNA strand breakage by a cationic meso-substituted porphyrin.}, author={Thomas M. Nicotera and Brenton Munson and Robert J. Fiel}, journal={Photochemistry and photobiology}, year={1994}, volume={60 4}, pages={295-300} }