• Chemistry, Medicine
  • Published in Anti-cancer drug design 2000

Photosensitization of pancreatic tumour cells by delta-aminolaevulinic acid esters.

@article{Whitaker2000PhotosensitizationOP,
  title={Photosensitization of pancreatic tumour cells by delta-aminolaevulinic acid esters.},
  author={Corinne Whitaker and Sinan Battah and Michael J. Forsyth and Christine E Edwards and Ross W Boyle and Edward K. Matthews},
  journal={Anti-cancer drug design},
  year={2000},
  volume={15 3},
  pages={
          161-70
        }
}
A series of straight chain, branched and cyclo-delta-aminolaevulinic acid (ALA) esters have been synthesized and their photosensitizing properties analysed using an in vitro system of rat pancreatoma cells. Structurally favourable ALA esters not only induced the formation of more of the endogenous photosensitizer, protoporphyrin IX (PpIX), but they did so at a faster rate than ALA itself. This action was reflected in a substantial increase in photocytotoxicity of some 270 times, using the more… CONTINUE READING

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Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis.

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