Photosensitization by norfloxacin is a function of pH.

  title={Photosensitization by norfloxacin is a function of pH.},
  author={Piotr J Bilski and Luis J Martinez and Edmond B Koker and Colin F. Chignell},
  journal={Photochemistry and photobiology},
  volume={64 3},
Norfloxacin is a fluoroquinolone (FQ) antibiotic that has been reported to cause cutaneous photosensitivity in animals and occasionally in humans. We have studied the fluorescence and singlet oxygen (1O2)-generating properties of norfloxacin. Upon UV excitation the drug fluoresces in water, and the relative intensities of two major fluorescence bands at ca 420 and 450 nm are affected by pH. The overall quantum yield of fluorescence (phi F) is also strongly pH dependent: phi F is low in 0.2 N… CONTINUE READING