Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis.

@article{Lopes2001PhotosensitizationAM,
  title={Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis.},
  author={Da{\'i}se Lopes and R R Oliveira and Maria Auxiliadora Coelho Kaplan and Claudia A.S. Lage and {\'A}lvaro C Leit{\~a}o},
  journal={Planta medica},
  year={2001},
  volume={67 9},
  pages={
          820-4
        }
}
Dorstenin, 5-[3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-butoxy]-7H-furo[3, 2-g] benzopyran-7-one, is a psoralen analog recently isolated from Dorstenia species (Moraceae). In order to characterize its biological activity, its photosensitizing and mutational properties were measured in wild-type E. coli and S. cerevisiae and also in strains carrying mutations which affect DNA repair. Compared to the high activities of psoralen and bergapten, dorstenin showed lower genotoxic effect. 
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