Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis.

  title={Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis.},
  author={Da{\'i}se Lopes and R R Oliveira and Maria Auxiliadora Coelho Kaplan and Claudia A.S. Lage and {\'A}lvaro C Leit{\~a}o},
  journal={Planta medica},
  volume={67 9},
Dorstenin, 5-[3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-butoxy]-7H-furo[3, 2-g] benzopyran-7-one, is a psoralen analog recently isolated from Dorstenia species (Moraceae). In order to characterize its biological activity, its photosensitizing and mutational properties were measured in wild-type E. coli and S. cerevisiae and also in strains carrying mutations which affect DNA repair. Compared to the high activities of psoralen and bergapten, dorstenin showed lower genotoxic effect. 
Evaluation of mutagenic activity in an extract of pepper tree stem bark (Schinus terebinthifolius Raddi)
Results indicate that pepper tree stem bark extract produces DNA damage and mutation in bacteria, and that oxidative damage may be responsible for the genotoxicity.
Evaluation of the antimutagenic and antiradical potentials of extracts from the tubers of (Tunisian) Cyperus rotundus
The mutagenic potential of aqueous, total oligomers flavonoids (TOF), ethyl acetate and methanol extracts from tubers of Cyperus rotundus L. was assessed using Ames Salmonella tester strains TA98 and
Atividades melanogênica, genotóxica e antiproliferativa de extratos de Brosimum gaudichaudii Trécul e Dorstenia brasiliensis Lam induzidas por radiação UVA.
This study analyzes extracts of species of the Cerrado containing furanocoumarins to evaluate their melanogenic, mutagenic and antiproliferative activities and reveals genotoxic activity in the in vivo Somatic Mutation And Recombination Test.
Phytochemical screening and evaluation of genotoxicity and acute toxicity of aqueous extract of Croton tiglium
Extensive and indiscriminate use of synthetic compounds and natural compounds obtained from plant sources have resulted into serious threats to not only the aquatic ecosystem but also to human
New insights on how nucleotide excision repair could remove DNA adducts induced by chemotherapeutic agents and psoralens plus UV-A (PUVA) in Escherichia coli cells.
Chemotherapeutic agents such as mitomycin C or nitrogen mustards induce DNA inter-strand cross-links (ICL) and are highly toxic, thus constituting an useful tool to treat some human degenerative
Morphoanatomical and preliminary phytochemical studies of two specimens of Dorstenia Contrajerva native to Guatemala
Most of the findings in this study, matches the ones reported for other authors to other species of Moraceae family, but many of them were no previously reported forother species of Dorstenia genus.
Evaluation of developmental toxicity and apoptotic induction of the aqueous extract of Millettia pachycarpa using zebrafish as model organism
Examination of the effects of exposure to aqueous extract of M. pachycarpa on early embryonic development of zebrafish embryos and mechanisms underlying toxicity suggest oxidative stress and apoptosis are associated with AEMP-induced embryonic lethality and developmental toxicity in zebra fish embryos.
Current Awareness
  • 2002
In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts.