Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization.

@article{Seto2013PhotosafetyAO,
  title={Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization.},
  author={Yoshiki Seto and Ryo Inoue and Masashi Kato and Shizuo Yamada and Satomi Onoue},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={2013},
  volume={120},
  pages={44-51}
}
Pirfenidone (PFD), an idiopathic pulmonary fibrosis drug, has phototoxic risk in clinical use, although its detailed mechanisms for the phototoxicity have never been fully elucidated. In the present study, the photochemical properties and in vitro phototoxicity of PFD were evaluated with a focus on ultraviolet absorption, reactive oxygen species (ROS… CONTINUE READING