Photoreceptor phagocytosis is mediated by phosphoinositide signaling.

  title={Photoreceptor phagocytosis is mediated by phosphoinositide signaling.},
  author={Debarshi Mustafi and Brian M Kevany and Christel Genoud and Xiaodong Bai and Krzysztof Palczewski},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={27 11},
Circadian oscillations in peripheral tissues, such as the retinal compartment of the eye, are critical to anticipating changing metabolic demands. Circadian shedding of retinal photoreceptor cell discs with subsequent phagocytosis by the neighboring retinal pigmented epithelium (RPE) is essential for removal of toxic metabolites and lifelong survival of these postmitotic neurons. Defects in photoreceptor phagocytosis can lead to severe retinal pathology, but the biochemical mechanisms remain… CONTINUE READING


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