Photoreactions of 3,3',4',5-tetrachlorosalicylanilide with proteins.

@article{Kochevar1977PhotoreactionsO3,
  title={Photoreactions of 3,3',4',5-tetrachlorosalicylanilide with proteins.},
  author={Irene E Kochevar and Leonard C. Harber},
  journal={The Journal of investigative dermatology},
  year={1977},
  volume={68 3},
  pages={
          151-6
        }
}
  • I. KochevarL. Harber
  • Published 1 March 1977
  • Chemistry, Biology
  • The Journal of investigative dermatology
The photoreactions of 3,3',4',5-tetrachlorosalicylanilide anion (TCSA-) with two serum proteins were studied. TCSA- and anions of two similar compounds, N-ethyl-3,5-dichlorosalicylamide and salicylanilide, bind noncovalently to human serum albumin (HSA) without irradiation in aqueous pH 7.4 buffered solutions. TCSA- noncovalently bound to HSA yields three types of photoproducts when irradiated with ultraviolet light (lambda greater than 360 nm). A covalently bonded photoadduct between TCSA- and… 
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78 Citations

The interaction of 3,3',4',5-tetrachlorosalicylanilide with phosphatidylcholine bilayers.

Binding of a spin-labelled photoallergen to human serum albumin.

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It was found that 3,4′,5-tribromosalicylanilide (Tbsa), which is notorious for causing photoallergy, forms stable photoconjugates on irradiation with glutathione and covalent binding with serum albumin appeared to be decreased in the presence of glutathion.

SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS‐XIV. THE SPIN TRAPPING OF FREE RADICALS FORMED DURING THE PHOTOLYSIS OF HALOGENATED SALICYLANILIDE ANTIBACTERIAL AGENTS

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EVIDENCE FOR A MAJOR STRONG BINDING SITE FOR TETRACHLOROSALICYLANILIDE ON HUMAN SERUM ALBUMIN

Evidence is shown for the existence of a major strong binding site for the photochemical binding of T4CS to HSA.

Radicals involved in photoallergen/protein interactions.

STRUCTURE AND PHOTOBIOLOGICAL ACTIVITY OF 7‐CHLORO‐1,4‐BENZODIAZEPINES. STUDIES ON THE PHOTOTOXIC EFFECTS OF CHLORDIAZEPOXIDE, DESMETHYLCHLORDIAZEPOXIDE AND DEMOXEPAM USING A BACTERIAL INDICATOR SYSTEM

Investigation of the photobiological activity of chlordiazepoxide and two of its metabolites found that a 4‐oxide moiety in the benzodiazepine nucleus is the structural characteristic responsible for the appearance of phototoxicity, and mutagenicity tests indicate that under the present experimental conditions photoproducts formed upon irradiated compounds with longwave UV light do not exert a mutagenic effect.

Photochemical reactions of fentichlor with soluble proteins.

Photochemical decomposition of 1,4-benzodiazepines. Chlordiazepoxide

The photochemical binding of bithionol to soluble proteins and peptides.

...

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Guinea pigs sensitized with p-chlorobenzoyl chloride showed, on the one hand, the usual surface lesions after application of the substance, and on the other typical anaphylactic shock following intravenous injection of a compound of p- chlorine chloride and guinea pig serum; from which it may be inferred that the two types of allergic manifestation are closely related conditions.

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