Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis.

@article{Moore2006PhotoprotectiveEO,
  title={Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis.},
  author={Julian O Moore and Yongyin Wang and William G Stebbins and Dayuan Gao and Xueyan Zhou and Robert Phelps and Mark G. Lebwohl and Huachen Wei},
  journal={Carcinogenesis},
  year={2006},
  volume={27 8},
  pages={1627-35}
}
Genistein, the most abundant isoflavone of the soy derived phytoestrogen compounds, is a potent antioxidant and inhibitor of tyrosine kinase. We previously reported the antiphotocarcinogenic effects of genistein in SKH-1 murine skin, including its capacity for scavenging reactive oxygen species, inhibiting photodynamic DNA damage and downregulating UVB(ultra violet B)-induced signal transduction cascades in carcinogenesis. In this study we elucidate genistein's photoprotective efficacy within… CONTINUE READING