Photoprotective and Antiinflammatory Effects of Topical Glycolic Acid

  title={Photoprotective and Antiinflammatory Effects of Topical Glycolic Acid},
  author={Nicholas V. Perricone},
  journal={Dermatologic Surgery},
  • N. Perricone
  • Published 1 May 1996
  • Medicine
  • Dermatologic Surgery
BACKGROUND Concerns about photosensitizing potential of alpha hydroxy acids have been expressed. A previous study, however, reported topical glycolic acid showing the opposite potential, that is, photoprotective. This study was designed to test the antiinflammatory and photoprotective capabilities of glycolic acid. OBJECTIVE The effects of short‐wave ultraviolet light (UVB) on skin treated with glycolic acid were evaluated in two different studies at two different locations. METHODS In the… 
Effects of glycolic acid on light-induced skin pigmentation in Asian and caucasian subjects.
Short-term topical treatment of glycolic acid caused an increase in UVB tanning as well as in UVA tanning in some subjects, even in the absence of overt irritation, and the inclusion of UVB, and even UVA, sunscreen in AHA products may be warranted.
α-Hydroxy Acid-Based Cosmetic Procedures
Abstractα-Hydroxy acid (AHA) peels and home regimens have recently been recognized as important adjunctive therapy in a variety of conditions including photodamage, actinic damage, melasma,
Effects of Topically Applied Glycolic Acid (GA) on the Sensitivity of Human Skin to UV-Induced Damage.
This study was conducted to investigate the effects of GA, applied in a cosmetic formulation, in modifying UV-sensitivity, and to determine whether the effect was reversible after discontinuing GA applications.
Mixing Glycolic Acid with Retinaldehyde: RALGA, a Technical Achievement
The best retinaldehyde-glycolic acid (RALGA) formulation developed had a low pH and, when stored at 40°C, revealed a good stability and the antibacterial activity of this formulation was also tested in vitro against Propionibacterium acnes and showed antibacterial results after only 5 min of contact.
Inhibitory effect of glycolic acid on ultraviolet‐induced skin tumorigenesis in SKH‐1 hairless mice and its mechanism of action
Results show that glycolic acid reduced UV‐induced skin tumor development and the inhibition of activation of transcription factors AP‐1 and NF‐κB could contribute significantly to the inhibitory effect of gly colic acid.
Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling.
Purpose We aimed to find active substances to help relieve the symptoms caused by increased photosensitivity after alpha hydroxy acid (AHA) peeling. Methods: A questionnaire survey was provided to 66
A Comparative Study to Assess the Safety and Efficacy Of 12 % Glycolic Acid V / S 10 % Azelaic Acid in the Treatment of Post Acne Hyperpigmentation
Hyperpigmentation reaction is thought to be a default pathophysiological response of dark skin to cutaneous injury and for patients the lingering effects of PIH is more disturbing than the actual acne itself, hence adjunctive treatment like microdermabrasion or chemical peels can give better results.


Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation is reduced by liposomal superoxide dismutase pretreatment.
Decreased SOD activity after UV exposure was reduced by pretreatment with liposomal SOD (L-SOD), which may have potential clinical application for photodermatologic reactions.
Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids.