Photonic crystal enhanced microscopy for imaging of live cell adhesion.

@article{Chen2013PhotonicCE,
  title={Photonic crystal enhanced microscopy for imaging of live cell adhesion.},
  author={Weili Chen and Kenneth D Long and Meng Lu and Vikram Chaudhery and Hojeong Yu and Ji Sun Choi and James Polans and Yue Zhuo and Brendan A. C. Harley and Brian T. Cunningham},
  journal={The Analyst},
  year={2013},
  volume={138 20},
  pages={
          5886-94
        }
}
A form of microscopy that utilizes a photonic crystal biosensor surface as a substrate for cell attachment enables label-free, quantitative, submicron resolution, time-resolved imaging of cell-surface interactions without cytotoxic staining agents or temporally-unstable fluorophores. Other forms of microscopy do not provide this direct measurement of live cell-surface attachment localization and strength that includes unique, dynamic morphological signatures critical to the investigation of… 
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An overview of cell refractive index models and measurement techniques including microfluidic chip-based techniques for the last 50 years are provided, the applications and significance of cellRefractive index in cell biology, hematology, and pathology are presented, and future research trends in the field are discussed.
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