Photolytic derivatization for improved LCEC determinations of pharmaceuticals in biological fluids.

  title={Photolytic derivatization for improved LCEC determinations of pharmaceuticals in biological fluids.},
  author={Carl M. Selavka and Ira S. Krull and Ira S. Lurie},
  journal={Journal of chromatographic science},
  volume={23 11},
Although electrochemical (EC) methods have been demonstrated to be sensitive and selective, wide use of EC detection in high performance liquid chromatographic (HPLC) assays in forensic and clinical toxicology laboratories has not been forthcoming. This fact is due to the general difficulty involved with the use of reductive EC detection methods, as well as to the lack of EC response in either the oxidative or reductive mode, for a number of classes of drugs having substantial clinical and… 
34 Citations

Liquid chromatography-photolysis-electrochemical detection for organoiodides. 1. Optimization and application.

An improved high-performance liquid chromatographic detection method has been applied for the trace determination of iodinated organic compounds and is successfully applied to the determination of liothyronine (T/sub 3/) in tablets.

Improved Determination of Nitrotoluenes Using Liquid Chromatography with Photolytically Assisted Thermal Energy Analysis (LC-PAT)

A post-column, on-line, photolysis unit is incorporated in a normal phase, high-performance liquid chromatography (LC) system to improve the thermal energy analyzer (TEA) detectability of mono-, di-

The Forensic Determination of Drugs of Abuse Using Liquid Chromatography with Electrochemical Detection: A Review

Liquid chromatography is particularly well suited for the analysis of a number of important controlled substances which are relatively nonvolatile, or thermally unstable, but the full potential of LC in the forensic analysis of drugs has not been met to date.

Ultraviolet Photolysis and Ortho-Phthalaldehyde-Mercaptoethanol Derivatization of Pharmaceuticals for Enhanced Fluorescence Detection in HPLC

Abstract Several classes of nitrogenous pharmaceutical were examined for fluorescence after ultraviolet (UV) radiation induced photolysis followed by reaction with o-phthalaldehyde-2-mercaptoethanol

Derivatization of ethylene dibromide with silica-supported silver picrate for improved high-performance liquid chromatographic detection.

Silica-supported silver picrate was used as an off-line, precolumn derivatization reagent for ethylene dibromide (EDB) and the results were confirmed with gas chromatography with electron capture detection (GC/ECD), the first report of an HPLC method for EDB.