Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis.

@article{Copley2008PhotolonAC,
  title={Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis.},
  author={Louise Copley and Pauline J. van der Watt and Karel W. A. Wirtz and Mohamed Iqbal Parker and Virna D. Leaner},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 2},
  pages={227-35}
}
Photolon is a photosensitiser with demonstrated potential as an anti-tumour agent. In this study, an in vitro investigation was performed to determine the mechanism of Photolon-induced cell death. Cell killing was observed in a light-dependent manner and light-activated Photolon resulted in a significant production of reactive oxygen species (ROS), which could be blocked by type I ROS scavengers. Inhibition of ROS production using Trolox prevented Photolon-induced cell death. Light-activated… CONTINUE READING
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