Photoleukomelanodermatitis (Kobori) Induced by Afloqualone

  title={Photoleukomelanodermatitis (Kobori) Induced by Afloqualone},
  author={Takayuki Ishikawa and Ryoichi Kamide and Michihito Niimura},
  journal={The Journal of Dermatology},
We reported a case of photoleukomelanodermatitis (Kobori) type drug eruption due to afloqualone (Arofuto®). The patient was given afloqualone and imipramine hydrochloride (Chrytemin®) for cervical spondylosis from November of 1990. Edematous erythema with slight itching appeared on the sun‐exposed areas in December of 1990. As drug eruption was suspected, drugs were ceased, and the cutaneous lesions almost disappeared but pigmentations and depigmentations developed in spots in sun‐exposed areas… 

Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide

We report a 68‐year‐old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with

Fixed Drug Eruption Due to Afloqualone: The First Reported Case

A 42-year-old Japanese female visited us with pinkish to brownish discoloration on her neck of 1 month duration and suspected a fixed drug eruption caused by afloqualone or bromazepam, a centrally acting muscle relaxant that was developed in Japan.

Leucoderma and leucotrichia in association with chronic cutaneous graft‐versus‐host disease

The patient, a 40-year-old woman with Crohn disease diagnosed in 2001, had had five previous laparotomies including a subtotal colectomy and ileo-anal pouch for severe colitis and she was otherwise well.

Acral papular neuromatosis: an early manifestation of Cowden syndrome

It is proposed that the patients, who developed leucoderma and leucotrichia in the context of GVHD, also have immunemediated melanocyte destruction, as a result of a specific immune response against the melanocytes triggered by the GV HD.

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The dyschromatoses with typical onset in adulthood are described, a group of pigmentary disorders characterized clinically by mixed and often guttate hypopigmentend and hyperpigmented lesions, and some acquired dyschromats are preventable and treatable.

Skin diseases described in Japan 2004

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In this article, skin diseases that were first established as distinct entities in Japan are reviewed in order to familiarize readers of the Western literature with these conditions.

Mechanisms of photosensitization induced by drugs: A general survey

A general survey of the mechanisms involved in drug phototoxicity is presented and a possible role of the arenediazonium ionsas photosensitisers is discussed.

Efficacy and safety of collagenase Clostridium histolyticum injection for Dupuytren’s contracture in non-Caucasian Japanese patients (CORD-J Study): the first clinical trial in a non-Caucasian population

A corrective effect on Dupuytren’s contracture and good tolerance were observed in most non-Caucasian (Asian) Japanese patients, confirming the efficacy of collagenase Clostridium histolyticum injections.

Protein Binding of Lapatinib and Its N- and O-Dealkylated Metabolites Interrogated by Fluorescence, Ultrafast Spectroscopy and Molecular Dynamics Simulations

Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity.

Coma and seizure caused by an afloqualone overdose

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Thiazide‐induced photosensitivity: a study of 33 subjects

The clinical features, action spectrum and subsequent course, are described in 33 subjects with thiazide‐induced photosensitivity, and in no instance, was there evidence of the induction of long‐term chronic photosensitivity (persistent light reaction) following the withdrawal of theThiazide drug.

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It was shown that the 2-(fluoromethyl) analogues possess in general more potent CNS depressant activities and less toxicities than their parent compounds.

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