Photolabile ruthenium complexes to cage and release a highly cytotoxic anticancer agent.


CHS-828 (N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N″-4-pyridyl guanidine) is an anticancer agent with low bioavailability and high systemic toxicity. Here we present an approach to improve the therapeutic profile of the drug using photolabile ruthenium complexes to generate light-activated prodrugs of CHS-828. Both prodrug complexes are stable in the dark but… (More)
DOI: 10.1016/j.jinorgbio.2017.11.018