Photoirradiation therapy of experimental malignant glioma with 5-aminolevulinic acid.

@article{Olzowy2002PhotoirradiationTO,
  title={Photoirradiation therapy of experimental malignant glioma with 5-aminolevulinic acid.},
  author={Bernhard Olzowy and Cornelia S Hundt and Susanne Stocker and Karl Bise and Hans J{\"u}rgen Reulen and Walter Stummer},
  journal={Journal of neurosurgery},
  year={2002},
  volume={97 4},
  pages={970-6}
}
OBJECT Accumulation of protoporphyrin IX (PPIX) in malignant gliomas is induced by 5-aminolevulinic acid (5-ALA). Because PPIX is a potent photosensitizer, the authors sought to discover whether its accumulation might be exploited for use in photoirradiation therapy of experimental brain tumors, without injuring normal or edematous brain. METHODS Thirty rats underwent craniotomy and were randomized to the following groups: 1) photoirradiation of cortex (200 J/cm2, 635-nm argon-dye laser); 2… CONTINUE READING