Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere.

@article{ViveroEscoto2009PhotoinducedIC,
  title={Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere.},
  author={Juan L. Vivero-Escoto and Igor I Slowing and Chian-Wen Wu and Victor S-Y Lin},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 10},
  pages={3462-3}
}
A gold nanoparticle (AuNP)-capped mesoporous silica nanosphere (MSN)-based intracellular drug delivery system (PR-AuNPs-MSN) for the photoinduced controlled release of an anticancer drug, paclitaxel, inside of human fibroblast and liver cells was synthesized and characterized. We found that the mesopores of MSN could be efficiently capped by the photoresponsive AuNPs without leaking the toxic drug, paclitaxel, inside of live human cells. This "zero premature release" characteristic is of… CONTINUE READING

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