Photoinduced electron-transfer reactions of carbonic anhydrase inhibitor containing tris(2,2'-bipyridine)ruthenium(II) analogue.

@article{Takashima2013PhotoinducedER,
  title={Photoinduced electron-transfer reactions of carbonic anhydrase inhibitor containing tris(2,2'-bipyridine)ruthenium(II) analogue.},
  author={Hiroshi Takashima and Misa Fukuda and Fumie Nakagaki and Tomoko Ogata and Keiichi Tsukahara},
  journal={The journal of physical chemistry. B},
  year={2013},
  volume={117 9},
  pages={
          2625-35
        }
}
A ruthenium(II) complex-based carbonic anhydrase (CA) inhibitor, [Ru(bpy)2(bpybs)](2+) {bpy = 2,2'-bipyridine and bpybs = 4'-methyl-2,2'-bipyridinyl-4-carboxylic acid (2-{2-[(4-sulphamoylbenzoylamino)ethoxy]ethoxy}ethyl)amide}, tethering a benzenesulfonamide group and a [Ru(bpy)3](2+) moiety has been prepared. The CA activity was effectively suppressed by a synthetic [Ru(bpy)2(bpybs)](2+) inhibitor, and the dissociation constant at pH 7.2 and at 25 °C was determined to be KI = 1.9 ± 0.2 μM… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 97 REFERENCES

Tosyl Chemistry for Protein Labeling in vivo

I. Ligand-Directed
  • Nat. Chem. Biol. 2009,
  • 2009

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