Photoinduced electron-transfer mechanisms for radical-enhanced photodynamic therapy mediated by water-soluble decacationic C₇₀ and C₈₄O₂ Fullerene Derivatives.

@article{Sperandio2013PhotoinducedEM,
  title={Photoinduced electron-transfer mechanisms for radical-enhanced photodynamic therapy mediated by water-soluble decacationic C₇₀ and C₈₄O₂ Fullerene Derivatives.},
  author={Felipe F. Sperandio and Sulbha K. Sharma and Min Wang and Seaho Jeon and Yingying Huang and Tianhong Dai and Suhasini Nayka and Suzana C.O.M. de Sousa and Long Y. Chiang and Michael R. Hamblin},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2013},
  volume={9 4},
  pages={
          570-9
        }
}
UNLABELLED Fullerenes are promising candidates for photodynamic therapy (PDT). Thus, C₇₀ and novel C₈₄O₂ fullerenes were functionalized with and without an additional deca-tertiary ethyleneamino-chain as an electron source, giving rise to two distinct pairs of photosensitizers, the monoadducts LC-17, LC-19 and the bisadducts LC18 and LC-20 to perform PDT in HeLa cells with UVA, blue, green, white and red light. Shorter wavelengths gave more phototoxicity with LC-20 while LC-19 was better at… CONTINUE READING

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