Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model.

@article{Goff1994PhotoimmunotherapyAB,
  title={Photoimmunotherapy and biodistribution with an OC125-chlorin immunoconjugate in an in vivo murine ovarian cancer model.},
  author={Barbara A. Goff and Ulrich Hermanto and Jim Rumbaugh and J. Blake and Michael P. Bamberg and Tayyaba Hasan},
  journal={British Journal of Cancer},
  year={1994},
  volume={70},
  pages={474 - 480}
}
Photodynamic therapy (PDT) is an experimental approach to the treatment of neoplasms in which photosensitisers (PSs) accumulated in malignant tissues are photoactivated with appropriate wavelengths of light. The target specificity of PSs may be improved by linking them with carrier macromolecules such as monoclonal antibodies (MAbs). OC125 is a murine MAb that recognises the antigen CA 125, which is expressed on 80% of non-mucinous ovarian tumours. A chlorin derivative conjugated to OC125 was… CONTINUE READING
24 Citations
33 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Cancer statistics

  • Y. GUILLAR
  • CA - A . Cancer J . Clin .
  • 1993

Photochemical targeting of cancer with macromolecular delivery systems

  • R. GRANSTEIN.R..ZURAWSKI.V.
  • Cancer Therapy into the Twenty - First Century…
  • 1993

Comparison of intravenous and intravesical administ - tion of ch } oro - aluminum sulfonated phthalocyaine for photodynamic treatment in a rat bladdur cancer model

  • M. SCHOLZ
  • J . Urol .
  • 1992

Enhanced photodynamic killing of target cells by either monoclonal antibody or low density lipoprotein mediated delivery systems

  • F. N.. RICHTER. A. M.. JAIN JIANG, G. A.K..LEVY.J., C. SMITS.
  • J . Controlled Release
  • 1992

Experimental photodynamic treatment of ovarian carcinoma cells with immunoconjugates

  • C. GOMER.
  • Antibody Immunoconj . Radiopharm .
  • 1992

How does photodynamnic therapy work ?

  • A. LEVY. J. G. JIANG. F. N.. JIANG. S.. LIU. D.. RICHTER
  • Photochem . Photobiol .
  • 1992

Photodymaic therapy of human cancer

  • D.. WAT. C. K.. TOWERS. G. H. MEW, G. LEVY.J.
  • Proc . IEEE
  • 1992

Photosensitizer delivery mediated by macromolecular carrier systems

  • B. Henderson, T. Dougherty.
  • Photodynamic Therapy : Basic Principles and…
  • 1992

Photoimmunotherapy of human ovanran carcinoma cells ex vivo

  • T. HASAN.
  • Cancer Res .
  • 1991

Similar Papers

Loading similar papers…