Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy.

@article{Traynor2005PhotogenotoxicityOH,
  title={Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy.},
  author={Nicola J Traynor and Paula E Beattie and Sally Helen Ibbotson and H. G. J. Moseley and James Ferguson and Julie A. Woods},
  journal={Toxicology letters},
  year={2005},
  volume={158 3},
  pages={220-4}
}
Extract of St. John's Wort (Hypericum perforatum) is commonly used as natural remedy for treatment of mild to moderate depression. However, it contains a powerful photoactive component, hypericin, which can cause a severe photodermatitis when eaten by grazing animals (hypericism). In humans, there is evidence that supplementation with St. John's Wort can reduce the minimal erythemal dose (MED) in patients undergoing high dose UVA-1 phototherapy. This is a recent development in phototherapy… CONTINUE READING