Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium.

@article{Wang2007PhotogeneratedGA,
  title={Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium.},
  author={Denong Wang and Gregory T. Carroll and Nicholas J. Turro and Jeffrey T Koberstein and Pavol Kov{\'a}{\vc} and Rina Saksena and Roberto Adamo and Leonore Herzenberg and Leonard A. Herzenberg and Lawrence Steinman},
  journal={Proteomics},
  year={2007},
  volume={7 2},
  pages={180-4}
}
Using photogenerated glycan arrays, we characterized a large panel of synthetic carbohydrates for their antigenic reactivities with pathogen-specific antibodies. We discovered that rabbit IgG antibodies elicited by Bacillus anthracis spores specifically recognize a tetrasaccharide chain that decorates the outermost surfaces of the B. anthracis exosporium. Since this sugar moiety is highly specific for the spores of B. anthracis, it appears to be a key biomarker for detection of B. anthracis… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…