Photofate of oseltamivir (Tamiflu) and oseltamivir carboxylate under natural and simulated solar irradiation: kinetics, identification of the transformation products, and environmental occurrence.

@article{Gonalves2011PhotofateOO,
  title={Photofate of oseltamivir (Tamiflu) and oseltamivir carboxylate under natural and simulated solar irradiation: kinetics, identification of the transformation products, and environmental occurrence.},
  author={Carlos Adriano Gonçalves and Sandra P{\'e}rez and Victoria Osorio and Mira Petrov{\'i}c and Maria F{\'a}tima Alpendurada and Dami{\'a} Barcel{\'o}},
  journal={Environmental science & technology},
  year={2011},
  volume={45 10},
  pages={4307-14}
}
In this work the photodegradation pathways and rates of oseltamivir ester (OE) and oseltamivir carboxylate (OC) were studied under artificial and natural solar irradiation with the goal of assessing the potential of photolysis as a removal mechanism in aquatic environments. The structures of the photoproducts of OE, elucidated by ultra performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry (UPLC-QToF-MS), were proposed to originate from hydration of the cyclohexene ring… CONTINUE READING