Photoendocrine transduction in cultured chick pineal cells: effects of light, dark, and potassium on the melatonin rhythm.

@article{Zatz1988PhotoendocrineTI,
  title={Photoendocrine transduction in cultured chick pineal cells: effects of light, dark, and potassium on the melatonin rhythm.},
  author={Martin Zatz and D A Mullen and Joseph r. Moskal},
  journal={Brain research},
  year={1988},
  volume={438 1-2},
  pages={199-215}
}
Several laboratories have demonstrated the persistence of photosensitive rhythms related to melatonin secretion in cultured chick pineals. We describe here a system using dispersed chick pineal cells in static culture, which displays a rhythm of melatonin release for at least two weeks under cyclic lighting conditions, and for at least 4 cycles under constant red light. Using a rapid and specific extraction assay for the [14C]melatonin formed (from [14C]tryptophan) and secreted by these cells… CONTINUE READING

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