Photodynamic treatment with fractionated light decreases production of reactive oxygen species and cytotoxicity in vitro via regeneration of glutathione.

@article{Oberdanner2005PhotodynamicTW,
  title={Photodynamic treatment with fractionated light decreases production of reactive oxygen species and cytotoxicity in vitro via regeneration of glutathione.},
  author={Christian Benno Oberdanner and Kristjan Plaetzer and Tobias Kiesslich and Barbara Krammer},
  journal={Photochemistry and photobiology},
  year={2005},
  volume={81 3},
  pages={609-13}
}
Photodynamic therapy removes unwanted or harmful cells by overproduction of reactive oxygen species (ROS). Fractionated light delivery in photodynamic therapy may enhance the photodynamic effect in tumor areas with insufficient blood supply by enabling the reoxygenation of the treated area. This study addresses the outcome of fractionated irradiation in an in vitro photodynamic treatment (PDT) system, where deoxygenation can be neglected. Our results show that fractionated irradiation with… CONTINUE READING

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