Photodynamic therapy with phthalocyanine sensitisation: quantitative studies in a transplantable rat fibrosarcoma.

@article{Tralau1987PhotodynamicTW,
  title={Photodynamic therapy with phthalocyanine sensitisation: quantitative studies in a transplantable rat fibrosarcoma.},
  author={C. J. Tralau and A. J. Macrobert and Philip D. Coleridge-Smith and Hugh Barr and Stephen G. Bown},
  journal={British Journal of Cancer},
  year={1987},
  volume={55},
  pages={389 - 395}
}
Photodynamic therapy (PDT) is a promising approach to the local destruction of malignant tumours, but little work has been done to determine which factors control the extent of tissue necrosis produced. Using a new photosensitiser, a sulphonated aluminium phthalocyanine (AlSPc) and light from an argon ion pumped dye laser at 675 nm, we quantified the effects of interstitial PDT in a transplantable fibrosarcoma in rats. At 100mW laser power, thermal effects were comparable to those of PDT, so… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Action spectrum ( 600 - 700 nm ) for chloroaluminium phthalocyanine induced phototoxicity in Chinese hamster cells

S. G. BOWN, C. J. TRALAU, T. J. WIEMAN
  • Lasers Life Sciences
  • 1986

Cell uptake , distribution and response to light of aluminium sulphonated phthalocyanine , a potential antitumour photosensitiser

P. D. COLERIDGE-SMITH, S. G. BOWN, T. N. MILLS, K. E. F. HOBBS, P. R. SALMON
  • Br . J . Cancer
  • 1986

Uptake and distribution of Aluminium Sulphonated Phthalocyanine (AlSPc) in rats bearing dimethylhydrazine (DMH) induced colon tumours

C. J. TRALAU, T. BARTON, H. BARR, M. R. LEWIN, S. G. BOWN
  • Proc. Brit
  • 1986

Photosensitised inactivation of Chinese hamster cells by phthalocynines

E. BEN-HUR
  • Photochem . Photobiol .
  • 1985

Synthesis , tissue distribution and tumour uptake of 99 mTc and 67 Gatetrasulfophthalocyanine

J. D. SPIKES
  • Int . J . Appl . Radiat . Isotopes
  • 1985

The interaction of tumourlocalising porphyrins with Collagen , elastin , gelatin , fibrin and fibrinogen

N. A. FRIGERIO
  • Cell Biochem . Funct .
  • 1985