Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration.

@article{Yoo2010PhotodynamicTW,
  title={Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration.},
  author={Kwang Ho Yoo and Jin Woong Lee and Kapsok Li and Beom Joon Kim and Myeung Nam Kim},
  journal={Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]},
  year={2010},
  volume={36 5},
  pages={618-22}
}
BACKGROUND Photodynamic therapy (PDT) with aminolevulinic acid or methyl 5-aminolevulinic acid (MAL) has been tried for the treatment of alopecia areata (AA). Unfortunately, the efficacy of PDT in treating AA is still being debated, and most clinical trials have produced disappointing results, which may have been because of the lack of treatment rationale or because of drug penetration. In several clinical trials of PDT in AA, the dermatologists suspected that skin preparations, including… CONTINUE READING
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