Photodynamic therapy with 5-aminolevulinic acid induces distinct microcirculatory effects following systemic or topical application.

@article{Schacht2006PhotodynamicTW,
  title={Photodynamic therapy with 5-aminolevulinic acid induces distinct microcirculatory effects following systemic or topical application.},
  author={Vivien Schacht and R M Szeimies and Christoph Abels},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  year={2006},
  volume={5 5},
  pages={452-8}
}
In photodynamic therapy (PDT) the photosensitiser 5-aminolaevulinic acid (ALA) can be used by systemic or topical application. Previous experiments showed that the photodynamic effects might not be mediated solely by porphyrins localized in the parenchyma, but also by porphyrins in the microvasculature. Therefore, the microcirculatory effects of PDT following systemic versus topical application of ALA have been investigated. Amelanotic melanomas were implanted in the dorsal skin fold chamber of… CONTINUE READING