Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan®) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients

  title={Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan{\textregistered}) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients},
  author={Kai Lorenz and Heinz Maier},
  journal={European Archives of Oto-Rhino-Laryngology},
  • K. LorenzH. Maier
  • Published 17 March 2009
  • Medicine
  • European Archives of Oto-Rhino-Laryngology
Photodynamic therapy (PDT) is a relatively new method of treating superficial tumours of the skin and mucosa. After the injection of a photosensitising agent, the tumour area is exposed to non-thermal laser light. This causes a phototoxic reaction, producing oxygen radicals that destroy tumour cells. From November 2003 to July 2007, a total of 35 patients with recurrent squamous cell carcinoma or secondary tumours of the head and neck region were treated with PDT at the German Armed Forces… 

Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx

PDT with Foscan® gives useful results in terms of survival and improvement in quality of life with few adverse events or severe complications and should be considered in the therapeutic armamentarium for recurrent carcinoma of the UADT.

Utility of photodynamic therapy for the management of oral potentially malignant disorders and oral cancer

According to the available data, PDT appears to be a safe, well-tolerated therapy with limited adverse effects and excellent cosmetic outcome, and further research is needed in order to investigate the cases that fail to respond and examine the long-term prognosis for cases of reported complete response.

Photofrin-mediated photodynamic therapy for treatment of early stage laryngeal malignancies

photoFRIN-mediated photodynamic therapy can be used as a primary modality to treat Tis-T1N0M0 tumors of the larynx or for treatment for those who have failed prior surgery and/or radiation therapy, allowing for preservation of function and structure to maintain or improve voice with absence of systemic toxicity.

Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy

Abstract Conclusion: Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure

Photodynamic Therapy (PDT): An Evolving Therapeutic Technique in Head and Neck Cancer Treatment

This chapter serves to provide a general background of the PDT technique and discusses how PDT is currently used clinically to treat head and neck cancers, as well as for aesthetic and cosmetic purposes.

Treatment of Malignant Neoplasms of the Nasal and Paranasal Sinuses by Photodynamic Laser Therapy (PDT) With Temoporfin

The experience with photodynamic therapy (PDT) used to treat four patients with recurring carcinomas in the area of the nasal and paranasal sinuses is reported on.

Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers

It is suggested that PDT is a promising treatment modality for early-stage SCCHN, and the low level of evidence of the included studies could help to design robust clinical trials to determine the efficacy of PDT inSCCHN.

Alternative Local Treatment in Oral Cavity Cancer: : Photodynamic Therapy

For some patients such treatments are not applicable, for example when adequate re-irradiation doses cannot be given due to previous therapy or when further surgery would be expected to lead to unacceptable functional morbidity, Photodynamic therapy (PDT) might be an alternative for these patients.

Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

A contemporary and comprehensive review on the role of photodynamic therapy in the treatment of (pre)malignancies of the UADT is presented and further clinical studies are needed to better define its true value in head and neck oncology.



Meta-tetra(hydroxyphenyl)chlorin photodynamic therapy in early-stage squamous cell carcinoma of the head and neck.

This study confirms that PDT is a powerful treatment modality that could be considered as an alternative to surgery or radiotherapy in specific cases of head and neck cancer, and reduces the reduction in long-term morbidity.

Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity

It is concluded that PDT offers an effective repeatable treatment option, whether on its own or as an adjunct to local excision, for patients with ’field cancerization‘ of the oral cavity.

mTHPC‐mediated photodynamic therapy for early oral squamous cell carcinoma

An open‐label, multicentre study to assess the efficacy and safety of meta‐tetrahydroxyphenylchlorin (mTHPC) in patients with early oral cancer concluded that mTHPC offers an effective alternative treatment for early oral squamous cell carcinoma.

Clinical pharmacokinetic studies of tetra(meta‐hydroxyphenyl)chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths

To optimize photodynamic therapy (PDT) and photodetection of cancer with second‐generation photosensitizers, knowledge of important variables such as the uptake of the dye and the dye contrast

Photodynamic Therapy of Head and Neck Cancer

This article will review the principle of PDT and the different indications for PDT of tumour of the head and neck, focusing on small and advanced tumours of the oral cavity and the larynx as well as papillomatosis of the laryx.

Photodynamic therapy and the treatment of head and neck cancers.

  • M. Biel
  • Medicine
    Journal of clinical laser medicine & surgery
  • 1996
Photodynamic therapy is an effective curative treatment for early carcinomas of the head and neck and may be of benefit as an adjuvant intraoperative therapy to increase cure rates of large head and

[Analysis of cost effectiveness of photodynamic therapy with Foscan (Foscan-PDT) in comparison with palliative chemotherapy in patients with advanced head-neck tumors in Germany].

Foscan-PDT is a cost-effective treatment option for patients suffering from advanced head and neck cancer and offers a chance for reduction of the tumor, remission, and a prolonged expectancy of life.

Weekly Paclitaxel and Carboplatin Combination Chemotherapy in Patients with Advanced Squamous Cell Carcinoma of the Head and Neck

Weekly administration of paclitaxel and carboplatin appears to be safe and efficacious in patients with advanced, metastatic or recurrent SCCHN.

Photodynamic therapy as an adjuvant intraoperative treatment of recurrent head and neck carcinomas

  • M. Biel
  • Medicine
    Photonics West - Lasers and Applications in Science and Engineering
  • 1994
Adjuvant intraoperative photodynamic therapy may improve cure rates in patients with recurrent head and neck malignancies by providing larger tumor-free margins of resection, while preserving normal structures.