Photodynamic therapy using pheophorbide-a and Q-switched Nd:YAG Laser on implanted human hepatocellular carcinoma

  title={Photodynamic therapy using pheophorbide-a and Q-switched Nd:YAG Laser on implanted human hepatocellular carcinoma},
  author={Yukitaka Yamashita and Fuminori Moriyasu and Shigeki Ono and Tohru Kimura and Kouzou Kajimura and Hitoshi Someda and Noriyuki Hamato and Motoshige Nabeshima and Masahiko Sakai and Minoru Okuma},
  journal={Gastroenterologia Japonica},
To evaluate whether administration of pheophorbide-a, a new photosensitizer, followed by use of Q-switched Nd:YAG Laser produces a photodynamic reaction, we administered pheophorbide-a to female nude mice (BALB/c-nu) that had been implanted with human hepatocellular carcinoma. Intra-tumoral concentrations of pheophorbide-a were measured by high-performance liquid chromatography. 3 hours after peroral administration of 1 mg/kg body weight, the intra-tumoral concentration was too low to reveal… CONTINUE READING
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