Photodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain.

@article{Jiang1998PhotodynamicTU,
  title={Photodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain.},
  author={Feng Jiang and Lothar Lilge and M Belcuig and Gajendra Singh and Julien Grenier and Yan Li and Michael Chopp},
  journal={Lasers in surgery and medicine},
  year={1998},
  volume={23 3},
  pages={161-6}
}
BACKGROUND AND OBJECTIVE The reactive oxygen mechanisms associated with cell damage after photodynamic therapy (PDT) may be exploited to enhance tumor destruction. Pharmacological reduction of glutathione (GSH), an inhibitor of reactive oxygen species, can be induced by administration of buthionine sulfoximine (BSO). STUDY DESIGN/MATERIALS AND METHODS BSO was administered in combination with Photofrin as the photosensitizer in order to promote PDT induced cell damage. Photofrin (12.5 mg/kg… CONTINUE READING