Photodynamic therapy using 5-aminolaevulinic acid for oesophageal adenocarcinoma associated with Barrett's metaplasia.

@article{Tan1999PhotodynamicTU,
  title={Photodynamic therapy using 5-aminolaevulinic acid for oesophageal adenocarcinoma associated with Barrett's metaplasia.},
  author={Wee Chiat Alan Tan and C A Fulljames and Nicholas Stone and Alan J. Dix and Neil A Shepherd and Drucilla Jane Roberts and Stanley B Brown and Neville Krasner and Hugh Barr},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={1999},
  volume={53 1-3},
  pages={75-80}
}
Photodynamic therapy (PDT) is a novel technique for local endoscopic treatment of gastrointestinal neoplasia. Current photosensitisers for PDT may cause prolonged skin phototoxicity. 5-Aminolaevulinic acid (ALA), a precursor of the photosensitiser protoporphyrin IX (PpIX), is more acceptable because of its short half-life and preferential accumulation in mucosa and mucosal tumour. We have treated 12 patients, median age 73 years (range 55-88) with oesophageal adenocarcinoma arising from Barrett… CONTINUE READING
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