Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters.

@article{Lopez2004PhotodynamicTO,
  title={Photodynamic therapy of skin cancer: controlled drug delivery of 5-ALA and its esters.},
  author={Renata Fonseca Vianna Lopez and Norbert Lange and Richard Guy and Maria Vit{\'o}ria Lopes Badra Bentley},
  journal={Advanced drug delivery reviews},
  year={2004},
  volume={56 1},
  pages={77-94}
}
Photodynamic therapy (PDT) is a tool for the treatment of certain cancerous and pre-cancerous conditions in dermatology. 5-Aminolevulinic acid (5-ALA) and simple derivatives thereof are the principal compounds used for this purpose. For optimal efficacy, the drug must be released at an appropriate rate from the formulation and penetrate the skin, ideally to reach the target tissue at a sufficiently high concentration. Because ALA is a polar, zwitterionic compound, its formulation in… CONTINUE READING
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