In conclusion, we would like to emphasize that photodynamic therapy can be used as a convenient and promising tool in the treatment of various malignancies in the head and neck area. It has to be stressed that PDT is still less effective in the treatment of more advanced cases of head and neck cancer. As the method of treatment which improves the quality of life, its usefulness can be considered as well as palliative treatment of non-operative cases. Although the method is not free of several side effects, such skin phototoxicity, burning, slight pain and edema in the irradiated location. All these side effects are transient and usually they disappear within 24 hours. The photodynamic treatment always results in excellent cosmetic effects without scarring or marring which are usually encountered after routine surgical operation.