Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha.

@article{Mitra2006PhotodynamicTM,
  title={Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha.},
  author={Soumya Mitra and Scott E Cassar and David J. Niles and John A Puskas and John G. Frelinger and Thomas H. Foster},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 12},
  pages={3268-74}
}
Photodynamic therapy (PDT) induces the expression of the hypoxia-inducible factor 1alpha (HIF-1alpha) subunit of the HIF-1 transcription factor and its target genes in vitro and in vivo. PDT also induces the expression of the enzyme cyclooxygenase-2 and its metabolite, prostaglandin E2 (PGE2). PGE2 and hypoxia act independently and synergistically to increase HIF-1alpha accumulation and nuclear translocation. To examine the expression of HIF-1 target genes in response to PDT-mediated oxidative… CONTINUE READING