Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter.

@article{Luna2000PhotodynamicTO,
  title={Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter.},
  author={Marian C. Luna and Arianna Ferrario and Stephen S. M. Wong and Anita M. R. Fisher and Charles J. Gomer},
  journal={Cancer research},
  year={2000},
  volume={60 6},
  pages={1637-44}
}
Oxidative stress associated with photodynamic therapy (PDT) is a transcriptional inducer of genes encoding stress proteins, including those belonging to the heat shock protein (hsp) family. The efficiency of PDT to function as a molecular switch by initiating expression of heterologous genes ligated to the human hsp promoter was examined in the present study. Selective and temporal reporter gene expression was documented after PDT in mouse radiation-induced fibrosarcoma cells stably transfected… CONTINUE READING
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