Photodynamic therapy for prostate cancer—a review of current status and future promise

@article{Moore2009PhotodynamicTF,
  title={Photodynamic therapy for prostate cancer—a review of current status and future promise},
  author={Caroline M. Moore and Doug Pends{\'e} and Mark Emberton},
  journal={Nature Clinical Practice Urology},
  year={2009},
  volume={6},
  pages={18-30}
}
Debate is ongoing about the treatment of organ-confined prostate cancer, particularly in men who have low-risk disease detected by PSA screening. A balance is needed between the harms and benefits of treatment. New techniques are being developed that aim to offer similar treatment effects to current radical therapies, while reducing the associated harmful effects of these treatments. In this Review, we explore the potential of one such technique, photodynamic therapy (PDT), for the treatment of… 

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References

SHOWING 1-10 OF 71 REFERENCES

Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer.

  • Kosmas E VerigosD. Stripp S. Hahn
  • Medicine, Physics
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 2006
TLDR
Optical property measurements demonstrated substantial heterogeneity in the optical properties of the human prostate gland which supports the use of individualized treatment planning for prostate PDT.

Focal therapy for prostate cancer

TLDR
Minimally invasive, parenchyma-preserving therapies can assume a greater role in the treatment of unilateral or unifocal lesions, representing an alternative approach to the current treatment extremes of whole-gland treatment and watchful waiting.

Photodynamic Therapy by Means of 5-ALA Induced PPIX in Human Prostate Cancer – Preliminary Results

TLDR
It is demonstrated that interstitial PDT of prostate cancer by means of 5-ALA induced PPIX is a safe and simple procedure and the PSA values were reduced by 20% up to 70%.

The Current Use and Future Trends of Focal Surgical Therapy in the Management of Localized Prostate Cancer

TLDR
The current rationale for and knowledge of MIT are addressed with regard to its safety and efficacy in the treatment of localized prostate cancer, and future promising tools in MIT such as photodynamic therapy and the target focal therapy approach as a new trend for the Treatment of organ-confined low-volume disease are discussed.

Interstitial photodynamic therapy in the canine prostate.

TLDR
Interstitial PDT in the canine prostate using Photofrin produced modest volumes of tissue necrosis, and the minimum light dose required to induce necrosis was variable because bleeding was unpredictable in relation to the optical fibre.
...