Photodynamic therapy for prostate cancer—a review of current status and future promise

  title={Photodynamic therapy for prostate cancer—a review of current status and future promise},
  author={Caroline M. Moore and Doug Pends{\'e} and Mark Emberton},
  journal={Nature Clinical Practice Urology},
Debate is ongoing about the treatment of organ-confined prostate cancer, particularly in men who have low-risk disease detected by PSA screening. A balance is needed between the harms and benefits of treatment. New techniques are being developed that aim to offer similar treatment effects to current radical therapies, while reducing the associated harmful effects of these treatments. In this Review, we explore the potential of one such technique, photodynamic therapy (PDT), for the treatment of… 

Photodynamic therapy in the treatment of prostate cancer

The results of these studies show that PDT is a selective, well-toler ated and efficient method of primary and salvage therapy of prostate cancer, particularly in the case of cancer resis tant to radiotherapy.

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

A general overview of the clinical applications of PDT in cancer, including the diagnostic and therapeutic approaches is provided, and combination of PDT with other therapy modalities such as chemotherapy, radiotherapy, surgery and immunotherapy will be emphasized, since such approaches seem to be promising in terms of enhancing effectiveness against tumor.

Photodynamic therapy in urology: what can we do now and where are we heading?

Focal Therapy of Prostate Cancer by Radiofrequency and Photodynamic Therapy

This chapter reviews the concept of focal therapy for prostate cancer, image-guided biopsy, and the role of imaging before focal therapy and more specifically considers the equipments, procedural technique, andThe efficacy of radiofrequency ablation for local prostate cancer.

Clinical development and potential of photothermal and photodynamic therapies for cancer

An overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments are provided.

Light penetration in the human prostate: a whole prostate clinical study at 763 nm.

This study assesses the penetration depth of 763 nm light throughout the prostate of men undergoing multiple hollow needle insertion for high dose rate brachytherapy and the effect of variability in light penetration, on the PDT effect.

Light-based therapies in prostate cancer treatment

An enhancement in cell killing in prostate carcinoma cells after PCI is concluded compared to PDT in 2-dimensional models, which indicates light based therapies could play an important role in prostate cancer treatment both eradicating tumours and generating long-term immune protection against secondary tumours.

Histopathology of prostate tissue after vascular-targeted photodynamic therapy for localized prostate cancer

Histopathological interpretation of post-WST11 VTP prostate biopsies was straightforward, in contrast with that of prostateBiopsies after radio or hormonal therapy, which introduces lesions difficult to interpret.

Photodynamic Therapy for Gynecological Diseases and Breast Cancer

The high degree of selectivity of the proposed method was applied to cancer diagnosis using fluorescence and the possibility of enhancing treatment efficacy by combination with immunotherapy and targeted therapy is discussed.



Updated results of a phase I trial of motexafin lutetium-mediated interstitial photodynamic therapy in patients with locally recurrent prostate cancer.

  • Kosmas E VerigosD. Stripp S. Hahn
  • Medicine, Physics
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 2006
Optical property measurements demonstrated substantial heterogeneity in the optical properties of the human prostate gland which supports the use of individualized treatment planning for prostate PDT.

Focal therapy for prostate cancer

Minimally invasive, parenchyma-preserving therapies can assume a greater role in the treatment of unilateral or unifocal lesions, representing an alternative approach to the current treatment extremes of whole-gland treatment and watchful waiting.

Photodynamic Therapy by Means of 5-ALA Induced PPIX in Human Prostate Cancer – Preliminary Results

It is demonstrated that interstitial PDT of prostate cancer by means of 5-ALA induced PPIX is a safe and simple procedure and the PSA values were reduced by 20% up to 70%.

The Current Use and Future Trends of Focal Surgical Therapy in the Management of Localized Prostate Cancer

The current rationale for and knowledge of MIT are addressed with regard to its safety and efficacy in the treatment of localized prostate cancer, and future promising tools in MIT such as photodynamic therapy and the target focal therapy approach as a new trend for the Treatment of organ-confined low-volume disease are discussed.

Interstitial photodynamic therapy in the canine prostate.

Interstitial PDT in the canine prostate using Photofrin produced modest volumes of tissue necrosis, and the minimum light dose required to induce necrosis was variable because bleeding was unpredictable in relation to the optical fibre.