Photodynamic therapy for cancer

@article{Dolmans2003PhotodynamicTF,
  title={Photodynamic therapy for cancer},
  author={Dennis Dolmans and Dai Fukumura and Rakesh K. Jain},
  journal={Nature Reviews Cancer},
  year={2003},
  volume={3},
  pages={380-387}
}
The therapeutic properties of light have been known for thousands of years, but it was only in the last century that photodynamic therapy (PDT) was developed. At present, PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin. How does PDT work, and how can it be used to treat cancer and other diseases? 
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  • Medicine
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2015
TLDR
A multidisciplinary view of the issues raised by the development of PDT is presented, showing how spectroscopy, photophysics, photochemistry and pharmacokinetics of photosensitizers determine the mechanism of cell death and clinical protocols.
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TLDR
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TLDR
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Biomodulatory approaches to photodynamic therapy for solid tumors.
TLDR
Basic principles of PDT, photosensitizers available, and aspects of tumor biology that may provide further opportunities for treatment optimization are described, and an emerging biomodulatory approach, using methotrexate or Vitamin D in combination with aminolevulinate-based PDT, is described.
Recent progress in tumor photodynamic immunotherapy
TLDR
The recent advances of PDT, immunotherapy, and photodynamic immunotherapy are reviewed and it is necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors.
Role of Nanocarriers in photodynamic therapy.
TLDR
Different nanocarriers systems has been developed and studied for their efficacy in PDT and forms the focal point of the review.
Photodynamic therapy – A novel and promising treatment for cancer
TLDR
The major difference between PDT and traditional cancer treatment is Photosensitizer of which is very specific in reaching only the infected or diseased tissues, but it has drawbacks, in combination with nanoparticles (NPs), which could be prevented.
A Review of Photodynamic Therapy for Neoplasms of the Head and Neck
TLDR
The mechanisms of action, historical development, available data, and current knowledge regarding PDT for the various head and neck subsites are reviewed, and possible future directions are discussed, with an emphasis on clinical application.
Photodynamic therapy: Combined modality approaches targeting the tumor microenvironment
TLDR
Photodynamic therapy causes direct cytotoxicity to malignant cells within a tumor, which can lead to PDT‐mediated angiogenesis and inflammation, which are emerging as important determinants of PDT responsiveness.
Photodynamic Therapy for Solid Tumor Therapy: No Longer Restricted by Hypoxia
TLDR
A mini review of diversified strategies made through delivery of ecdemic oxygen and intracellular replenishment of oxygen during PDT for better therapy efficacy in solid tumors.
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TLDR
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