Photodynamic therapy and the immune system in experimental oncology.

  title={Photodynamic therapy and the immune system in experimental oncology.},
  author={Gianfranco Canti and Alessandra De Simone and Mladen Korbelik},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  volume={1 1},
Photodynamic therapy (PDT), a newly established treatment for solid tumors, involves the systemic administration of a tumor localizing photosensitizer that is only activated when exposed to light of appropriate wavelength. Photoactivation of the photosensitizer in the presence of oxygen results in the generation of highly cytotoxic molecular species. The PDTmediated antitumor effect is oxygen dependent and is the consequence of direct cytotoxicity and an antivascular effect which impairs blood… CONTINUE READING
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