Photodynamic therapy: A mitochondrial inducer of apoptosis

  title={Photodynamic therapy: A mitochondrial inducer of apoptosis},
  author={David Kessel and Yu Luo},
  journal={Cell Death and Differentiation},
Photodamage to the mitochondria of murine leukemia P388 cells resulted in immediate loss of the mitochondrial membrane potential together with the release of cytochrome c into the cytosol. This was followed by a rapid activation of caspase 3-like proteases, as indicated by a marked rise in DEVDase activity. There was no significant effect on WEHDase or VEIDase activities, suggesting that only the late-stage caspases had been effected. The apoptotic response to mitochondrial photodamage was… CONTINUE READING
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