Photodynamic induction of DNA-protein cross-linking in solution by several sensitizers and visible light.

@article{Villanueva1993PhotodynamicIO,
  title={Photodynamic induction of DNA-protein cross-linking in solution by several sensitizers and visible light.},
  author={Angeles Villanueva and Magdalena Ca{\~n}ete and C Carmen Trigueros and Luis Rodr{\'i}guez-Borlado and Angeles Juarranz},
  journal={Biopolymers},
  year={1993},
  volume={33 2},
  pages={
          239-44
        }
}
The combined effect of several sensitizers and light on H2O or D2O solutions of DNA-histone complexes, as well as the significance of singlet oxygen (1O2), in this photosensitizing reaction has been studied. On H2O solutions, the production of 1O2, as well as the formation of DNA-protein cross-links (DPCs), were found to be dependent on light dose for all the sensitizers. Mesotetra (4N-methylpyridyl) porphine (T4MPyP), methylene blue (MB), and toluidine blue (TB) were the best photosensitizers… CONTINUE READING
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