Photodynamic ablation of high-grade dysplasia and early cancer in Barrett's esophagus by means of 5-aminolevulinic acid.

@article{Gossner1998PhotodynamicAO,
  title={Photodynamic ablation of high-grade dysplasia and early cancer in Barrett's esophagus by means of 5-aminolevulinic acid.},
  author={Liebwin Gossner and Manfred Stolte and Ronald Sroka and Kyle Rick and Andrea May and Eckhart G. Hahn and C. Ell},
  journal={Gastroenterology},
  year={1998},
  volume={114 3},
  pages={448-55}
}
BACKGROUND & AIMS The first therapeutic experiences with the conventional photosensitizer dihematoporphyrinester in the treatment of Barrett's esophagus show the curative potential of photodynamic therapy (PDT). The aim of this study was to test 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX, a photosensitizer with a high mucosa specificity without phototoxic side effects on the skin, as a new form of PDT. METHODS Thirty-two patients (mean age, 68.5 years) with histologically proven… CONTINUE READING

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