Photodegradation pathways and the in vitro phototoxicity of pyrazinamide, a phototoxic antitubercular drug.

@article{Vargas2003PhotodegradationPA,
  title={Photodegradation pathways and the in vitro phototoxicity of pyrazinamide, a phototoxic antitubercular drug.},
  author={F. Vargas and C. Rivas and Y. D{\'i}az and A. Fuentes},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={2003},
  volume={72 1-3},
  pages={
          87-94
        }
}
The phototoxic antitubercular drug pyrazinamide (1) is photolabile under irradiation with UV-A light as well as with a N2 laser (at 337 nm) in aerobic conditions. Irradiation in methanolic and in aqueous solutions of 1 produces four and three photoproducts, respectively. Their formation involves primary alpha-cleavage between the excited carbonyl of the amido group and the aromatic ring followed by hydrogen abstraction and dimerization. Pyrazinamide was able to cause photohemolysis in human… Expand
9 Citations
In vitro evaluation of betamethasone esters for phototoxic potential
  • 5
Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity
  • 7
  • PDF

References

SHOWING 1-10 OF 28 REFERENCES
Screening test for phototoxins using solutions of simple biochemicals.
  • W. Lovell, D. Sanders
  • Chemistry, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 1990
  • 23
Biochemistry and pathology of radical-mediated protein oxidation.
  • 1,541
  • PDF
Oxygen radicals in biological systems.
  • L. Packer
  • Chemistry, Medicine
  • Methods in enzymology
  • 1984
  • 334
  • PDF
Free radical toxicology
  • 65
Glutathione disulfide (GSSG) efflux from cells and tissues.
  • 201
...
1
2
3
...