Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.

  title={Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin.},
  author={Florian Schuett and Sallyanne Davies and Jurgen Kopitz and Frank G. Holz and Michael Boulton},
  journal={Investigative ophthalmology & visual science},
  volume={41 8},
PURPOSE A fluorescent component of lipofuscin, A2-E (N-retinylidene-N-retinylethanol-amine) has been shown to impair lysosomal function and to increase the intralysosomal pH of human retinal pigment epithelial (RPE) cells. In addition to its lysosomotropic properties A2-E is known to be photoreactive. The purpose of this study was to determine the phototoxic potential of A2-E on RPE cells. METHODS A2-E (synthesized by coupling all-trans-retinaldehyde to ethanolamine) was complexed to low… CONTINUE READING
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