Photochemistry of benzophenone immobilized in a major groove of DNA: formation of thermally reversible interstrand cross-link.

Abstract

We here report a highly site and sequence selective formation of an interstrand cross-link of (BP)U-containing oligomer duplexes. The cross-link was found spontaneously reverted to original oligomers upon heating, providing a new method for the temporary connection of two DNA strands. 

Topics

Cite this paper

@article{Nakatani2002PhotochemistryOB, title={Photochemistry of benzophenone immobilized in a major groove of DNA: formation of thermally reversible interstrand cross-link.}, author={Kazuhiko Nakatani and Takashi Yoshida and Isao Saito}, journal={Journal of the American Chemical Society}, year={2002}, volume={124 10}, pages={2118-9} }