Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA.

Abstract

Photochemical internalization (PCI) has been employed as a tool for site-specific intracellular delivery of a variety of molecules. In this study, for the first time, PCI has been employed to facilitate the endosomal escape of small interfering RNA (siRNA) molecules, which are the functional mediators of RNA interference (RNAi). In order to interact with… (More)

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