Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate.

@article{Wang2012PhotochemicalIO,
  title={Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate.},
  author={Julie T-W. Wang and Francesca Giuntini and Ian M. Eggleston and Stephen G. Bown and Alexander J. Macrobert},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={157 2},
  pages={305-13}
}
Photochemical internalisation (PCI) is a site-specific technique for improving cellular delivery of macromolecular drugs. In this study, a cell penetrating peptide, containing the core HIV-1 Tat 48-57 sequence, conjugated with a porphyrin photosensitiser has been shown to be effective for PCI. Herein we report an investigation of the photophysical and photobiological properties of a water soluble bioconjugate of the cationic Tat peptide with a hydrophobic tetraphenylporphyrin derivative. The… CONTINUE READING

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