Photochemical control of the infectivity of adenoviral vectors using a novel photocleavable biotinylation reagent.

@article{Pandori2002PhotochemicalCO,
  title={Photochemical control of the infectivity of adenoviral vectors using a novel photocleavable biotinylation reagent.},
  author={Mark W. Pandori and David A Hobson and Jerzy Olejnik and Edyta Krzymanska-Olejnik and Kenneth J Rothschild and Abraham A Palmer and Tamara J Phillips and Takeshi Sano},
  journal={Chemistry & biology},
  year={2002},
  volume={9 5},
  pages={567-73}
}
We have explored a novel strategy for controlling the infectivity of adenoviral vectors. This strategy involves a method whereby the infectivity of adenoviral vectors is neutralized by treatment of viral particles with a water-soluble, photocleavable biotinylation reagent. These modified viral vectors possess little to no infectivity for target cells… CONTINUE READING