Photocaging strategy for functionalisation of oligonucleotides and its applications for oligonucleotide labelling and cyclisation.

Abstract

We have used a photocaging strategy to develop novel phosphoramidites and expand the repertoire of protecting groups for modification of oligonucleotides by solid-phase synthesis. We synthesised five photolabile phosphoramidites and four new photolabile controlled pore glasses (CPGs). By using these photolabile phosphoramidites and CPGs, modified… (More)
DOI: 10.1002/chem.201103833

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