Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms.

@article{Finlay2004PhotobleachingKO,
  title={Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms.},
  author={Jarod Finlay and Soumya Mitra and Michael S. Patterson and Thomas H. Foster},
  journal={Physics in medicine and biology},
  year={2004},
  volume={49 21},
  pages={
          4837-60
        }
}
We present a detailed investigation of Photofrin photobleaching and photoproduct accumulation. Fisher rats were sensitized with 10 mg kg(-1) Photofrin and irradiated 24 h later with 514 nm light at 5 or 100 mW cm(-2). Fluorescence spectra were collected from the skin throughout treatment, and sensitizer bleaching and fluorescent photoproduct formation were quantified using spectral analysis. Photofrin bleaching was slightly more rapid at the higher irradiance under these conditions. However… CONTINUE READING
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