Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals.

Abstract

The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.

DOI: 10.1002/chem.201605285

Cite this paper

@article{AnayaPlaza2017PhotoantimicrobialBB, title={Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals.}, author={Eduardo Anaya-Plaza and Eveline van de Winckel and Joona Mikkil{\"a} and Jani-Markus Malho and Olli Ikkala and {\`O}scar Gul{\'i}as and Roger Bresol{\'i}-Obach and Montserrat Agut and Santi Nonell and Tom{\'a}s Torres and Mauri A Kostiainen and Andr{\'e}s de la Escosura}, journal={Chemistry}, year={2017}, volume={23 18}, pages={4320-4326} }